|
KMID : 0351219920240010001
|
|
Korean Journal of Infectious Diseases
1992 Volume.24 No. 1 p.1 ~ p.12
|
|
|
Activity of Cefepime against Enterobacter cloacae Serratia marcescens, Pseudomonas aeruginosa and other aerobic gram-negative bacilli
|
|
|
|
|
Abstract
|
|
|
Infections due to such resistant bacteria as Citrobacter freundii, Enterobacter cloacae, Serratia marcescens and Pseudomonas aeruginosa became increasingly serious treatment problem at large medical centers, in Korea. Cefepime was reported to be
more
active than other cephalosporins against these problem organisms. The activity of cefepime against the bacteria isolated mostly from inpatients at a hospital in Seoul, in 1991, were tested by the agar dilution method. Among the antimicrobial
agents
tested, cefepime showed the lowest MIC90 against C. freundii and E. cloacae, 0.12㎍/ml and 8㎍/ml, respectively MIC90 of cefepime and amikacin, 8㎍/ml, was the lowest against S. marcescens. MIC90 of cefepime, ceftazidime and doxycycline, 32㎍/ml,
were
the lowest against Acinetobacter anitratus. Against P. aeruginosa, the MIC90 was relatively high, 32㎍/ml, but still the lowest. Among the cefotacime-resistant E. cloacae-only 7% showed resistance to cefepime, while 100%, 96% and 89% were
resistant
to
ceftazidime, ceftizoxime and cefuzonam, respectively. Again, only 6% of gentamicin-resistant isolates were resistant to cefepime, compared to 91%, 72%, 69% and 63% to ceftazidime, ceftizoxime, cefuzonam and cefotaxime, respectively. The highly
active in
vitro test result should indicate the usefulness of cefepime for the treatment of various gram-negative bacilli infections including nosocomial ones.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|